Hsa -mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis
نویسندگان
چکیده
منابع مشابه
Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis
MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer, heart disease, neurological disorders, vascular abnormalities and autoimmune conditions. Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer, the data have yielded conflicting results. Therefore, this meta-analysis was performed to provide a co...
متن کاملHsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies
BACKGROUND Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive. METHODOLOGY/PRINCIPAL FINDINGS We conducted a meta-analysis of 12 studies that inclu...
متن کاملmiR-499 rs3746444 polymorphism and coronary artery disease risk: a meta- analysis
Background: Some studies suggested that miR-499 rs3746444 polymorphism was associated with the risk of Coronary Artery Disease (CAD). However, the results were still unclear. Therefore, we conducted a meta-analysis. Method: An electronic literature search was conducted using the following database: PubMed, Embase and China National Knowledge Infrastructure (CNKI) till to June 2017. The strength...
متن کاملAssociation of miR-196a2 rs11614913 and miR-499 rs3746444 polymorphisms with cancer risk: a meta-analysis
Background MicroRNAs (miRNAs) are small non-coding RNA molecules, which participate in diverse biological processes and may regulate tumor suppressor genes or oncogenes. Rs11614913 in miR-196a2 and rs3746444 in miR-499 are shown to associate with increased/decreased cancer risk. This meta-analysis was performed to systematically assess the overall association. Materials and Methods We searche...
متن کاملAn A/G polymorphism rs3746444 in miR-499 is associated with increased cancer risk: a meta-analysis.
An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the association between the rs3746444 polymo...
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ژورنال
عنوان ژورنال: Journal of Biomedical Research
سال: 2012
ISSN: 1674-8301
DOI: 10.7555/jbr.26.20110122